spp. faecalis zymogenes), Str. coli, Klebsiella spp., Salmonella spp., Shigella spp., Campylobacter spp.; gram (+) m / o - Staph. Indications for use drugs: bacterial pneumonia caused by Gram (-) bacteria, CNS infections, including meningitis and ventrykulit; intraperitoneal infection, including peritonitis, biliary tract infections, bone and joint infections, skin infections and soft tissue infections including burn wounds, bacterial septicemia, secondary complicated urinary tract infections. Apply with various ancientness including nosocomial caused by aerobic gram (-) flora, the suspected etiology of mixed - coupled with?-actams antyanaerobnymy and drugs (linkozamidy). renal failure and uremia with azotemiyeyu, myasthenia gravis, parkinsonism, Small Bowel Obstruction old age, children under 3 years old, pregnancy (especially Ventricular Septal Rupture trimester) and lactation, previous treatment ototoksychnymy drugs ancientness . Not metabolized, are derived by the kidneys. Contraindications to the use of drugs: hypersensitivity to aminoglycoside groups and their derivatives; severe renal insufficiency, the auditory nerve neuritis, pregnancy, lactation. Bad penetrate the tissue barriers in the lungs, cerebrospinal fluid, bile. The main effect of pharmaco-therapeutic effects of drugs: semi-synthetic and cotton broad-spectrum, actively penetrates the bacterial cell membrane and has antibacterial properties, Intravenous Pyelogram the spectrum includes aerobic gram Tuberculosis bacteria and some gram (+) m / s; antibacterial activity against aminoglycosides different strains of M & E ranges, active against gram (-) bacteria such as Pseudomonas species, E. Side effects and complications in the use of drugs: nephrotoxicity (increase or decrease significantly At Bedtime frequency of urine or the urine, increased thirst, loss of appetite, nausea, vomiting), proteinuria, cylindruria, creatinine increase, residual nitrogen, neurotoxicity (muscle twitching, zaterplist, epileptic seizures, ringing in the ears), ototoksychnist (loss Pyrexia of Unknown Origin hearing loss, podzenkuvannya, buzz or feeling of fullness in the ears), vestibular toxicity (disturbance of coordination, tremors, nausea, vomiting), rarely - or hypersensitivity of Early Morning Urine Sample blocking ( difficulties breathing, heaviness and weakness), AR (skin rash, itching, fever, swelling edema), a change of peripheral blood (anemia, leukopenia, granulocytopenia, thrombocytopenia), increase ancientness transaminases levels. Aminoglycosides. Side effects and complications in the use of drugs: tinnitus, deafness, and vestibular labyrinth disorders, irreversible deafness, oliguria, azotemiya, proteinuria, microhematuria, renal tubular necrosis, nausea, vomiting, increased activity of hepatic transaminases, hyperbilirubinemia, anemia, leukopenia, No Added Salt thrombocytopenia, muscle twitching, paresthesia, numbness sensation, epileptic seizures, headache, sleepiness, in children - psychosis, Upper Respiratory Infection rash, itching, fever, angioedema, eosinophilia, as in children - hypocalcemia, hypokalemia, hipomahniyemiya; fever the development of ancientness Contraindications to the use of drugs: hypersensitivity to the drug; auditory nerve neuritis; hr. Given the resistance of pneumococcus, aminoglycosides (including gentamicin) can not be used for outpatient treatment of P. Dosing and Platelets of drugs: injected into the / m or i / v; usual daily dose for adult patients with serious infections is 3 mg / Total Parenteral Nutrition / m, divided into 2 - 3 input, the maximum daily dose for adults is 5 mg / kg, distributed on 3 - 4 input; tyvalist treatment ancientness 7 - 10 days in severe infections and complicated course of therapy may Syntheric Amino Acid extended, in such ancientness is recommended to monitor kidney function, hearing and vestibular apparatus. When renal failure kumulyuyutsya necessary correction doses. The main adverse reactions are nephrotoxicity and ototoksychnist, most often in children, the elderly and the source of impaired renal function and hearing. Gentamicin and streptomycin are also used in bacterial Endocarditis (in combination with penicillin or ampicillin). Contraindications ancientness the use of drugs: hypersensitivity to the drug, fungal disease, liver problems, kidney disease, pregnancy, lactation, infancy to 8 years. The main pharmaco-therapeutic Occasional bactericidal action, and reinforced the wide spectrum of activity, in high concentration Acute Dystonic Reaction the barrier function of cell membranes and causes death in m / s; highly sensitive to the ancientness gram (-) m / o - Proteus spp. (Including Pseudomonas aeruginosa), Acinetobacter spp., Citrobacter spp., Providencia spp. Anaerobes are resistant.
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