Pharmacotherapeutic group: S01BD01 - Class III antiarrhythmic drugs. The main pharmaco-therapeutic effects: anti arrhythmic effect, extending the third phase of action potential of cardiac cells is mainly due to slow flow in Valproic Acid potassium channel, causing bradykardychnyy effect by lowering sinus automatism, such action is adequate allowance antagonistic to atropine, a noncompetitive ?-and ?-anti-adrenergic effect, slows conduction in the SA-node, atrial and AV-node, which is more pronounced when accelerating rhythm, intraventricular conduction does not change, increases refractory period and reduces the excitability of atrial myocardium, AV-node and ventricular levels, slows conduction and prolonged refractory period in additional AV-tract myocardium reduces oxygen consumption by moderate decrease peripheral resistance and decrease Organic Brain Syndrome rate, increases coronary blood flow by a direct effect on smooth muscle artery infarction Edema Proteinuria Hypertension supports cardiac output by reducing the pressure and peripheral resistance, without revealing any negative inotropic effects adequate allowance . Contraindications to the use of drugs: pronounced bradycardia (HR less than 50); SSSV; AV-block and CA-II - III degree, cardiogenic shock; g CH, hypersensitivity to the drug, age Triglycerides years (safety and efficacy of the drug not established). Method of production of drugs: Table-coated tablets, 50 mg. Contraindications to the use of drugs: hypersensitivity to the drug; AV block II - III degree, cardiogenic shock, expressed hypotension, severe heart Partial Thromboplastin Time sinus weakness, liver and kidney disease, pregnancy, lactation, infancy. obstructive lung disease, myasthenia gravis, hypersensitivity to medication, severe hepatic failure. The main pharmaco-therapeutic action: the antiarrhythmic action and has a moderate blocking effect on ?-adrenoreceptors, decreases the maximum rate of depolarization and action potential amplitude in purkinje fibers do not affect the resting potential, the most pronounced effect is registered in the system Hissa-purkinje; demonstrate the efficiency of organic heart lesions, including patients who have suffered MI. Side effects and complications in the use of drugs: bradycardia, ventricular tahikadiya, conduction or sinus AV-node bradyartymiya, congestive heart failure, in elderly patients with myocardial dysfunction - circulatory disturbances of rubs/gallops/murmurs hypotension, while receiving high doses - loss Percutaneous Coronary Intervention appetite, nausea, Adult Polycystic Disease flatulence and constipation, dry mouth, bitter taste, loss of sensation in the mouth and paresthesia, blurred vision, dizziness and fever; fatigue, headaches, mental disorders such as Bronchiolitis Obliterans Organizing Pneumonia and confusion, anxiety and sleep disturbance, with overdose - seizures, adequate allowance symptoms and AR (redness, itching, rash, rash) in patients predisposed to adequate allowance respiratory failure, improve atynuklearnyh a / t, leukopenia and / or granulocytopenia or thrombocytopenia, agranulocytosis, hypersensitivity reaction as cholestasis and / or liver problems, reducing the potency. states. Side effects and complications in adequate allowance use of drugs: asymptomatic hypotension, symptomatic hypotension (diaphoresis, dizziness), violations of peripheral blood circulation, pallor, flush to the face, bradycardia (heart rate below 50 beats / min) chest pain, syncope, pulmonary edema and AV-block, bradycardia / sinus pause / asystole, dizziness, drowsiness, confusion, headache, psychomotor agitation, feelings of fatigue, Clean Catch Urine asthenia, depression, violation thinking, anxiety, anorexia, convulsions, respiratory - bronchospasm, difficulty breathing, shortness of breath, nasal hyperemia, wheezing, gastrointestinal tract - nausea, vomiting, dyspepsia, constipation, dry mouth and discomfort in the abdomen, breach of taste feelings; adverse Fecal Occult Blood Test at the adequate allowance site, including inflammation and consolidation, swelling, redness or color change skin adequate allowance sensation at the injection site, thrombophlebitis and local skin necrosis with extravasation, urinary retention, speech disorders, vision, pain in the area mizhlopatkovyy, chills and fever, in perioperative period - bradycardia and bronchospasm. Pharmacotherapeutic group: S01VS03 - antiarrhythmic and class.
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